Nasty Virus Assignment

Bio 101 Lab November 2-3

You will be organized into 3 or 4 teams by your discussion or lab instructor during lab October 19-20. Each group will research one of the "organisms" listed below.

1. Antibiotic resistant strains of bacteria
2. HIV
3. Mad Cow Disease

Bring your information to lab class November 2-3 and be prepared to work with your groupmates to prepare a brief presentation including the following information.

(Note - you are welcome to split up the work and have one or two people work on each category of information for your disease.)

• History - origin, identification, and reservoir (where the pathogen is found in nature).

• Epidemiology – spread, prevention, and treatment of the disease.

• The Mode of action of the “organism”, including the structure and reproduction - how does its DNA and/or proteins interact with the victim's cells and/or medicines used to treat the disease.

This last category will require you to dig into the disease and investigate it on a moleculer level, so look for resources that provide the needed detail. The basic CNN news story will probably not provide what you need.

You should find information related to the DNA, gene expression, and protein synthesis topics we have discussed in class.

Here are some starting points that you might find useful:

HIV/AIDS

• HIV reproduction and treatments. Youtube video 5:14
• HIV Life Cycle Youtube video 3:09
• HIV Replication - Hoefnagels pg. 362, fig 17.7
• Understanding HIV and AIDS (HIV #1) Youtube video 3:32
• When HIV Becomes AIDS (HIV #2) Youtube video 3:52
• Testing for HIV (HIV #3) Youtube video 3:17
• Treating HIV (HIV #4) Youtube video 4:15
• HIV's not-so-ancient history - Evolution in the News - Youtube video - first 4 minutes deals with HIV evolution
• NIAID-Supported Scientists Discover Origin of HIV-1 (National Institute of Allergy and Infectious Diseases)

Antibiotic Resistance


• Combating Antibiotic Resistance
• Antibiotic Resistance --Its Impact on a Great Medical Center in the Last 30 Years
• Antibiotic Resistance
• Mechanism of Antibiotic Resistance
• Spread of Antibiotic Resistance
• Evolution of Antibiotic Resistance
• Multiple Drug Resistance
• Killer Microbe PBS/NOVA Video 8:29

BSE - Mad Cow Disease

• BSE (Bovine Spongiform Encephalopathy, or Mad Cow Disease) from CDC
  
• Prion Diseases from CDC
• Prion From Wikipedia
• Mad Cow, HIV and more - origin of new diseases (From PBS/NOVA)
• Mad Cow Disease youtube video :45
  

Self-Search Strategies

• Health Topics A to Z from Centers for Disease Control and Prevention
• Google searches often produce good results. Use Google to search the "web" and "Images".

Here are some appropriate key words and phrases

• For Antibiotic Resistance: antibiotic resistance, antibiotic resistant bacteria, antibiotic resistance evolution, antibiotic resistance mutation
• For HIV: HIV, AIDS, retrovirus, reverse transcriptase, AZT, protease inhibiters
• For Mad Cow Disease: mad cow disease, prion diseases, Creutzfeldt-Jakob disease (CJD), variant Creutzfeldt-Jakob disease (variant CJD)