Text Readings in Lewis	Review questions
Chapters 13 - 16 Review Chapter 17 All for lectures 17 - 19	pg. 391: 9 and 10

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Objectives
After studying this material you should be able to:

1. Describe the inheritance of a mutation that results in the manifestation of a genetic disorder. Describe the roles of DNA and proteins in such a disorder.

2. Describe the goals of the Human Genome Project and and the relationship of the project to the understanding of genetic diseases.

3. List and explain in general terms the three questions that must be answered in an attempt to prevent or treat a genetic disorder.

4. Explain in general terms the goals of and concerns about somatic gene therapy.

5. Discuss the issues involved in the use of gene testing to identify a potential genetic disorder.

6. Define biotechnology in its broad and narrow sense.

7. Describe the general goals of biotechnology

Web resources:

These sites contain a wealth of information concerning genetics, DNA, and Biotechnology. I will include links to specific topics in the body of the outlines for this lecture and lectures 18 and 19, however I invite you to explore on your own. There might be potential net surfer projects here.

• From Maps to Medicine: About the Human Genome Research Project

• Understanding Gene Testing
  U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
  Public Health Service National Institutes of Health National Cancer Institute
  Accessed from Access Excellence a web site managed by Genentech, a biotechnology company in California

• Access Excelence Graphics Gallery

• Principles Of Biotechnology North Central Regional Extension Publication Iowa State University - University Extension

• Biotechnology - The Future from Access Excellence

• The Washington Biotechnology Action Council This organization provides an alternative view of the potential benefits of biotechnology

• See Lewis' Text page 361-2

• Inheritance of Autosomal Recessive Trait

• Gene Expression & the Role of Proteins
  • How are genes linked to disease?

  • How does a faulty gene trigger disease?

  • How do gene mistakes occur?

The Human Genome Project

The Human Genome Project (History & Mission)

Goals of the Human Genome Project:

• to construct detailed genetic and physical maps of the human genome,

• to determine the complete nucleotide sequence of human DNA,

• to localize the estimated 50,000-100,000 genes within the human genome,

• and to perform similar analyses on the genomes of several other organisms used extensively in research laboratories as model systems.

• How to Conquer A Genetic Disease

• Lactose Intolerance

• Somatic gene Therapy

• See also Lewis, p. 372 - SCID - The Evolution of a Cure and p. 388 - 389 Gene Therapy for Mendelian Disorders.

• CF GENE THERAPY BEGINS By Sean Henahan, Access Excellence

• Pioneer James Wilson Reflects On Gene Therapy's Hopes, Hype

• What is gene testing?

• What are the uses of genetic testing?

• What are the benefits of gene testing?

• What are the limitations of gene testing?

• What are the risks of gene testing?

• Principles of Biotechnology North Central Regional Extension Publication Iowa State University - University Extension

Biotechnology - The Future from Access Excellence

Take me home.